A native of Montreal, QC, Patrice Brisebois starred with Montreal Bourassa in the Quebec Midget AAA Hockey League before joining the QMJHL in 1987-88. He amassed 370 points in four seasons with the Laval Titan and the Drummondville Voltigeurs. He impressed during a ten-game trial at the end of the 1990-91 season then started the next season in the AHL with the Fredericton Canadiens. Brisebois was summoned late in the 1991-92 schedule and became a regular on the Montreal blue line the following year.
After having reached the Memorial Cup tournament three times in his junior career (1989, 1990 and 1991), the young blueliner's first full season in the NHL culminated in a Stanley Cup championship. Brisebois scored ten goals in the regular season and demonstrated poise as the club moved deeper into the playoffs. In 1997-98, he scored 37 points, registered a +16 plus/minus rating and helped the Habs reach the second round of the playoffs. As the franchise struggled in the late 1990s, Brisebois was a constant on the defensive brigade. He set a personal high with 15 goals in 2000-01 and was an integral part of the club's playoff hopes in 2001-02.
During the 2002-03 season, Brisebois surpassed the 700 game plateau and registered his 300th career point before ending his playing days in Montreal following the 2003-04 season. After spending his entire NHL career with Montreal, Brisebois was acquired by the Colorado Avalanche in the summer of 2005.
Brisebois patrolled the Colorado blue-line and proved to be a steady defender with the Avalanche in 2005-06. The following year he suffered a serious back injury in a December 27, 2006 game against the Dallas Stars. The injury kept him out of the Avalanche line-up for the remainder of the season and Brisebois signed as a free with the Canadiens in the summer of 2007 where he would complete his NHL career having played in 1,009 games.
On the international stage, Brisebois is a two-time member of Canada's World Junior team (1990-1991).